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rabbit anti-tryptophan hydroxylase (tph2) #pa1-778  (Thermo Fisher)


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    Thermo Fisher rabbit anti-tryptophan hydroxylase (tph2) #pa1-778
    Rabbit Anti Tryptophan Hydroxylase (Tph2) #Pa1 778, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rabbit+anti-tph2/rabbit+anti+tph2/pm40593635-503-60-63
    Average 90 stars, based on 1 article reviews
    rabbit anti-tryptophan hydroxylase (tph2) #pa1-778 - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Blocking Assay:

    Article Title: Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat.
    Article Snippet: It has been proposed that serotonin (5-HT) facilitates the chemosensory activity of the carotid body (CB).. In the present study, we investigated mRNA expression and immunohistochemical localization of the 5-HT synthetic enzyme isoforms, tryptophan hydroxylase 1 (TPH1) and TPH2, and the 5-HT plasma membrane transport protein, 5-HT transporter (SERT), in the CB of the rat.. RT-PCR analysis detected the expression of mRNA for TPH1 and SERT in extracts of the CB.

    Article Title: Exposure to Acute and Chronic Fluoxetine has Differential Effects on Sociability and Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus of Juvenile Male BALB/c Mice.
    Article Snippet: Although the neurobiological mechanisms underlying autism spectrum disorder (ASD) are still unknown, dysregulation of serotonergic systems has been implicated in the etiology of ASD, and serotonergic antidepressant drugs are often prescribed to treat some symptoms of ASD.. The BALB/c strain of mice express a dysregulated serotonergic system and a phenotype that is relevant to ASD.. In this study, juvenile male BALB/c mice were exposed to the selective serotonin reuptake inhibitor fluoxetine either chronically (18 mg/kg/day in drinking water, post-natal day (PND) 28–39) or acutely (18 mg/kg, i.p.; PND40), or to vehicle control conditions (0.9% sterile saline, i.p.; PND40), prior to being exposed to the three-chambered sociability test (SAT; PND40).

    Article Title: Acute treatment with 5-hydroxytryptophan increases social approach behaviour but does not activate serotonergic neurons in the dorsal raphe nucleus in juvenile male BALB/c mice: A model of human disorders with deficits of sociability.
    Article Snippet: Background: The BALB/c mouse has been proposed as a model of human psychiatric disorders characterised by elevated anxiety and altered sociability.. Juvenile BALB/c mice show decreased social exploratory behaviour, increased anxiety, and reduced brain serotonin synthesis compared to other strains including C57BL/6J mice.. Aim: To determine whether supplementation of brain serotonin synthesis alters social behaviour and activation of serotonergic neurons across subregions of the dorsal raphe nucleus (DR) in BALB/c mice.

    Article Title: Mitochondrial changes and oxidative stress in a mouse model of Zellweger syndrome neuropathogenesis.
    Article Snippet: Various combinations of primary antibodies were used: mouse antiGFAP, at a dilution of 1:800 (Sapphire Biosciences, Waterloo, NSW, Australia); rabbit anti-IBA-1, 1:2000 (Wako Chemicals, Richmond, VA, USA); goat antitryptophan hydroxylase-2 (TPH2) (Everest Biotech Ltd, Oxfordshire, UK), rabbit anti-TPH2 (ThermoFisher Scientific, Inc, Rockford, IL, USA), rabbit anti-5HT (Sigma Aldrich Ltd, NSW, Australia); rabbit anti-SOD2, 1:500 (Abcam plc, Cambridge, UK), sheep anti-SOD2, 1:1000 (EMD Millipore, Billerica, MA, USA), rabbit anti-NOS, 1:500 (Merck Millipore, Billerica, Massachusetts, USA), mouse anti-PMP70, 1:600 (Maxwell et al., 2003), rabbit anti-PEX14 (Maxwell et al., 2003), rabbit anti-PGC-1a (Santa Cruz Biotech Inc., Dallas, TX, USA).

    Article Title: Central serotonergic neuron deficiency in a mouse model of Zellweger syndrome.
    Article Snippet: 63 Abstract—Zellweger syndrome (ZS) is a severe peroxisomal disorder caused by mutations in peroxisome biogenesis, or PEX, genes.. A central hallmark of ZS is abnormal neuronal migration and neurodegeneration, which manifests as widespread neurological dysfunction.. The molecular basis of ZS neuropathology is not well understood.

    Article Title: Impaired neurogenesis and associated gliosis in mouse brain with PEX13 deficiency.
    Article Snippet: Multiple combinations of primary antibodies were used: mouse anti-GFAP, (1:800,Sapphire Biosciences); rabbit anti-GFAP, (1:800, Merck-Millipore); rabbit anti-Iba-1, (1:2000, Wako Chemicals); goat anti-Iba-1, (1:500, Abcam); goat anti-TPH2, (1:750, Everest Biotech); rabbit anti-Tph2, (1:750, ThermoFisher Scientific, Inc. Rockford, IL, USA); rabbit anti-β-III tubulin (or Tuj-1), (1:1000, ThermoFisher Scientific); mouse anti-NeuN, (1:100, Merck-Millipore); rabbit anti-Ki67, (1:200, Cell Signalling Technology); and rabbit anti-cleaved caspase3, (1:400, Cell Signalling Technology).

    Article Title: The Role of Dorsal Raphe Nucleus Serotonergic Systems in Emotional Learning and Memory in Male BALB/c Mice.
    Article Snippet: Elsevier Inc. All rights reserved. label c-Fos-expressing cells; 2) rabbit anti-Tph2 (1:20000; Thermo Fisher, Cat. No. PA1-778, Lot No. RK238110) to label serotonergic neurons; and 3) biotinylated goat antirabbit (1:500; Vector Elite, Cat. No. PK-6101).

    Incubation:

    Article Title: Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat.
    Article Snippet: It has been proposed that serotonin (5-HT) facilitates the chemosensory activity of the carotid body (CB).. In the present study, we investigated mRNA expression and immunohistochemical localization of the 5-HT synthetic enzyme isoforms, tryptophan hydroxylase 1 (TPH1) and TPH2, and the 5-HT plasma membrane transport protein, 5-HT transporter (SERT), in the CB of the rat.. RT-PCR analysis detected the expression of mRNA for TPH1 and SERT in extracts of the CB.

    Article Title: Exposure to Acute and Chronic Fluoxetine has Differential Effects on Sociability and Activity of Serotonergic Neurons in the Dorsal Raphe Nucleus of Juvenile Male BALB/c Mice.
    Article Snippet: Although the neurobiological mechanisms underlying autism spectrum disorder (ASD) are still unknown, dysregulation of serotonergic systems has been implicated in the etiology of ASD, and serotonergic antidepressant drugs are often prescribed to treat some symptoms of ASD.. The BALB/c strain of mice express a dysregulated serotonergic system and a phenotype that is relevant to ASD.. In this study, juvenile male BALB/c mice were exposed to the selective serotonin reuptake inhibitor fluoxetine either chronically (18 mg/kg/day in drinking water, post-natal day (PND) 28–39) or acutely (18 mg/kg, i.p.; PND40), or to vehicle control conditions (0.9% sterile saline, i.p.; PND40), prior to being exposed to the three-chambered sociability test (SAT; PND40).

    Article Title: Acute treatment with 5-hydroxytryptophan increases social approach behaviour but does not activate serotonergic neurons in the dorsal raphe nucleus in juvenile male BALB/c mice: A model of human disorders with deficits of sociability.
    Article Snippet: Background: The BALB/c mouse has been proposed as a model of human psychiatric disorders characterised by elevated anxiety and altered sociability.. Juvenile BALB/c mice show decreased social exploratory behaviour, increased anxiety, and reduced brain serotonin synthesis compared to other strains including C57BL/6J mice.. Aim: To determine whether supplementation of brain serotonin synthesis alters social behaviour and activation of serotonergic neurons across subregions of the dorsal raphe nucleus (DR) in BALB/c mice.

    Article Title: Mitochondrial changes and oxidative stress in a mouse model of Zellweger syndrome neuropathogenesis.
    Article Snippet: Various combinations of primary antibodies were used: mouse antiGFAP, at a dilution of 1:800 (Sapphire Biosciences, Waterloo, NSW, Australia); rabbit anti-IBA-1, 1:2000 (Wako Chemicals, Richmond, VA, USA); goat antitryptophan hydroxylase-2 (TPH2) (Everest Biotech Ltd, Oxfordshire, UK), rabbit anti-TPH2 (ThermoFisher Scientific, Inc, Rockford, IL, USA), rabbit anti-5HT (Sigma Aldrich Ltd, NSW, Australia); rabbit anti-SOD2, 1:500 (Abcam plc, Cambridge, UK), sheep anti-SOD2, 1:1000 (EMD Millipore, Billerica, MA, USA), rabbit anti-NOS, 1:500 (Merck Millipore, Billerica, Massachusetts, USA), mouse anti-PMP70, 1:600 (Maxwell et al., 2003), rabbit anti-PEX14 (Maxwell et al., 2003), rabbit anti-PGC-1a (Santa Cruz Biotech Inc., Dallas, TX, USA).

    Article Title: Central serotonergic neuron deficiency in a mouse model of Zellweger syndrome.
    Article Snippet: 63 Abstract—Zellweger syndrome (ZS) is a severe peroxisomal disorder caused by mutations in peroxisome biogenesis, or PEX, genes.. A central hallmark of ZS is abnormal neuronal migration and neurodegeneration, which manifests as widespread neurological dysfunction.. The molecular basis of ZS neuropathology is not well understood.

    Article Title: Impaired neurogenesis and associated gliosis in mouse brain with PEX13 deficiency.
    Article Snippet: Multiple combinations of primary antibodies were used: mouse anti-GFAP, (1:800,Sapphire Biosciences); rabbit anti-GFAP, (1:800, Merck-Millipore); rabbit anti-Iba-1, (1:2000, Wako Chemicals); goat anti-Iba-1, (1:500, Abcam); goat anti-TPH2, (1:750, Everest Biotech); rabbit anti-Tph2, (1:750, ThermoFisher Scientific, Inc. Rockford, IL, USA); rabbit anti-β-III tubulin (or Tuj-1), (1:1000, ThermoFisher Scientific); mouse anti-NeuN, (1:100, Merck-Millipore); rabbit anti-Ki67, (1:200, Cell Signalling Technology); and rabbit anti-cleaved caspase3, (1:400, Cell Signalling Technology).

    Article Title: The Role of Dorsal Raphe Nucleus Serotonergic Systems in Emotional Learning and Memory in Male BALB/c Mice.
    Article Snippet: Elsevier Inc. All rights reserved. label c-Fos-expressing cells; 2) rabbit anti-Tph2 (1:20000; Thermo Fisher, Cat. No. PA1-778, Lot No. RK238110) to label serotonergic neurons; and 3) biotinylated goat antirabbit (1:500; Vector Elite, Cat. No. PK-6101).



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    rabbit anti-tryptophan hydroxylase (tph2) #pa1-778  (Thermo Fisher)
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    a. Strategy for labeling DRN 5-HT neurons projecting to the VTA and the vCPU. AAV11-DIO-EGFP was bilaterally injected into the vCPU of Sert -Cre mice, and AAV11-DIO-mCherry was injected into both sides of the VTA. b. Images of retrogradely labeled DRN 5-HT neurons. Violet, anti-TPH2 antibody; mCherry⁺ cells, Sert DRN→VTA neurons; EGFP⁺ cells, Sert DRN→vCPU neurons. c. Percentages of three types of DRN 5-HT neurons in the DRN ( n = 7 mice). d. HyPer7 recordings of type III neurons. Strategy for labeling type III neurons and representative confocal image showing that type III neurons mainly locate in the ventral part of the DRN. e. Attack-locked rHF traces of type III neurons in response to a 10-day CSDS. The black lines indicate the onset of attacks. f. Mean attack-locked rHF of type III neurons in SUS and RES mice during a 10-day CSDS paradigm ( n = 6/12 in SUS/RES mice, respectively). g. HyPer7 recordings of Sert DRN→VTA neurons. h. Attack-locked rHF traces of Sert DRN→VTA neurons following a 10-day CSDS. i. Mean attack-locked rHF of type I neurons in SUS and RES mice ( n = 5/8 in SUS/RES mice). j. HyPer7 recordings of Sert DRN→vCPU neurons. k. Attack-locked rHF traces of Sert DRN→vCPU neurons following a 10-day CSDS. l. Mean attack-locked rHF of type II neurons in SUS and RES mice ( n = 6/6 in SUS/RES mice). Scale bars, 100 μm; * p < 0.05 and *** p < 0.001. f, i, l, two-way RM ANOVA with Sidak’s multiple comparisons test. # p < 0.05, # # p < 0.01, and # # # p < 0.001 relative to the basal level (dashed line) by one-sample t -test ( f, i, l ). n.s., not significant. Data are presented as mean ± SEM.

    Journal: bioRxiv

    Article Title: Serotonergic neurons in the dorsal raphe nucleus scale O₂ utilization in response to traumatic stress

    doi: 10.64898/2026.01.14.699586

    Figure Lengend Snippet: a. Strategy for labeling DRN 5-HT neurons projecting to the VTA and the vCPU. AAV11-DIO-EGFP was bilaterally injected into the vCPU of Sert -Cre mice, and AAV11-DIO-mCherry was injected into both sides of the VTA. b. Images of retrogradely labeled DRN 5-HT neurons. Violet, anti-TPH2 antibody; mCherry⁺ cells, Sert DRN→VTA neurons; EGFP⁺ cells, Sert DRN→vCPU neurons. c. Percentages of three types of DRN 5-HT neurons in the DRN ( n = 7 mice). d. HyPer7 recordings of type III neurons. Strategy for labeling type III neurons and representative confocal image showing that type III neurons mainly locate in the ventral part of the DRN. e. Attack-locked rHF traces of type III neurons in response to a 10-day CSDS. The black lines indicate the onset of attacks. f. Mean attack-locked rHF of type III neurons in SUS and RES mice during a 10-day CSDS paradigm ( n = 6/12 in SUS/RES mice, respectively). g. HyPer7 recordings of Sert DRN→VTA neurons. h. Attack-locked rHF traces of Sert DRN→VTA neurons following a 10-day CSDS. i. Mean attack-locked rHF of type I neurons in SUS and RES mice ( n = 5/8 in SUS/RES mice). j. HyPer7 recordings of Sert DRN→vCPU neurons. k. Attack-locked rHF traces of Sert DRN→vCPU neurons following a 10-day CSDS. l. Mean attack-locked rHF of type II neurons in SUS and RES mice ( n = 6/6 in SUS/RES mice). Scale bars, 100 μm; * p < 0.05 and *** p < 0.001. f, i, l, two-way RM ANOVA with Sidak’s multiple comparisons test. # p < 0.05, # # p < 0.01, and # # # p < 0.001 relative to the basal level (dashed line) by one-sample t -test ( f, i, l ). n.s., not significant. Data are presented as mean ± SEM.

    Article Snippet: Free-floating sections were washed in PBS three times, 5 min/wash, permeabilized with 0.3% Triton X-100 in PBS for 30 min, blocked in blocking solution containing 5% normal goat serum and 0.3% Triton X-100 for 2 h at room temperature, and then stained with a rabbit polyclonal anti-TPH2 primary antibody (1:300, NB100-74555; Novus Biologicals) overnight at 4°C.

    Techniques: Labeling, Injection